BIO-MAS Lab Biophysics of Intracellular Organization - Mechanics And Superresolution

Highlighted

Smart lattice light-sheet microscopy for imaging rare and complex cellular events
Smart lattice light-sheet microscopy for imaging rare and complex cellular events
Yu Shi, Jimmy S. Tabet, Daniel E. Milkie, Timothy A. Daugird, Chelsea Q. Yang, Alex T. Ritter, Andrea Giovannucci, Wesley R. Legant
Nature Methods  ·  02 Jan 2024  ·  doi:10.1038/s41592-023-02126-0
Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment
Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment
Timothy A. Daugird, Yu Shi, Katie L. Holland, Hosein Rostamian, Zhe Liu, Luke D. Lavis, Joseph Rodriguez, Brian D. Strahl, Wesley R. Legant
Nature Communications  ·  16 May 2024  ·  doi:10.1038/s41467-024-48562-0
Dissecting fat-tailed fluctuations in the cytoskeleton with active micropost arrays
Dissecting fat-tailed fluctuations in the cytoskeleton with active micropost arrays
Yu Shi, Christopher L. Porter, John C. Crocker, Daniel H. Reich
Proceedings of the National Academy of Sciences  ·  25 Jun 2019  ·  doi:10.1073/pnas.1900963116

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2024

Posterior approach to correct for focal plane offsets in lattice light-sheet structured illumination microscopy
Posterior approach to correct for focal plane offsets in lattice light-sheet structured illumination microscopy
Yu Shi, Tim A. Daugird, Wesley R. Legant
Journal of Biomedical Optics  ·  31 Jul 2024  ·  doi:10.1117/1.jbo.29.8.086502
Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment
Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment
Timothy A. Daugird, Yu Shi, Katie L. Holland, Hosein Rostamian, Zhe Liu, Luke D. Lavis, Joseph Rodriguez, Brian D. Strahl, Wesley R. Legant
Nature Communications  ·  16 May 2024  ·  doi:10.1038/s41467-024-48562-0
Smart lattice light-sheet microscopy for imaging rare and complex cellular events
Smart lattice light-sheet microscopy for imaging rare and complex cellular events
Yu Shi, Jimmy S. Tabet, Daniel E. Milkie, Timothy A. Daugird, Chelsea Q. Yang, Alex T. Ritter, Andrea Giovannucci, Wesley R. Legant
Nature Methods  ·  02 Jan 2024  ·  doi:10.1038/s41592-023-02126-0

2023

Lévy distributed fluctuations in the living cell cortex
Lévy distributed fluctuations in the living cell cortex
Shankar Sivarajan, Yu Shi, Katherine M. Xiang, Clary Rodríguez-Cruz, Christopher L. Porter, Geran M. Kostecki, Leslie Tung, John C. Crocker, Daniel H. Reich
arXiv  ·  01 Jan 2023  ·  doi:10.48550/arXiv.2309.06226

2022

A quantitative analysis of various patterns applied in lattice light sheet microscopy
A quantitative analysis of various patterns applied in lattice light sheet microscopy
Yu Shi, Timothy A. Daugird, Wesley R. Legant
Nature Communications  ·  08 Aug 2022  ·  doi:10.1038/s41467-022-32341-w
Measuring Cytoskeletal Mechanical Fluctuations and Rheology with Active Micropost Arrays
Measuring Cytoskeletal Mechanical Fluctuations and Rheology with Active Micropost Arrays
Yu Shi, Shankar Sivarajan, John C. Crocker, Daniel H. Reich
Current Protocols  ·  01 May 2022  ·  doi:10.1002/cpz1.433
A multi-functional microfluidic device compatible with widefield and light sheet microscopy
A multi-functional microfluidic device compatible with widefield and light sheet microscopy
Regan P. Moore, Ellen C. O’Shaughnessy, Yu Shi, Ana T. Nogueira, Katelyn M. Heath, Klaus M. Hahn, Wesley R. Legant
Lab on a Chip  ·  01 Jan 2022  ·  doi:10.1039/D1LC00600B

2021

Pervasive cytoquakes in the actomyosin cortex across cell types and substrate stiffness
Pervasive cytoquakes in the actomyosin cortex across cell types and substrate stiffness
Yu Shi, Shankar Sivarajan, Katherine M Xiang, Geran M Kostecki, Leslie Tung, John C Crocker, Daniel H Reich
Integrative Biology  ·  01 Oct 2021  ·  doi:10.1093/intbio/zyab017
Optogenetic current in myofibroblasts acutely alters electrophysiology and conduction of co-cultured cardiomyocytes
Optogenetic current in myofibroblasts acutely alters electrophysiology and conduction of co-cultured cardiomyocytes
Geran M. Kostecki, Yu Shi, Christopher S. Chen, Daniel H. Reich, Emilia Entcheva, Leslie Tung
Scientific Reports  ·  24 Feb 2021  ·  doi:10.1038/s41598-021-83398-4

2020

Force-dependent trans-endocytosis by breast cancer cells depletes costimulatory receptor CD80 and attenuates T cell activation
Force-dependent trans-endocytosis by breast cancer cells depletes costimulatory receptor CD80 and attenuates T cell activation
Seungman Park, Yu Shi, Byoung Choul Kim, Myung Hyun Jo, Leilani O. Cruz, Zheming Gou, Taekjip Ha, Li-Fan Lu, Daniel H. Reich, Yun Chen
Biosensors and Bioelectronics  ·  01 Oct 2020  ·  doi:10.1016/j.bios.2020.112389

2019

Dissecting fat-tailed fluctuations in the cytoskeleton with active micropost arrays
Dissecting fat-tailed fluctuations in the cytoskeleton with active micropost arrays
Yu Shi, Christopher L. Porter, John C. Crocker, Daniel H. Reich
Proceedings of the National Academy of Sciences  ·  25 Jun 2019  ·  doi:10.1073/pnas.1900963116

2015

A microfabricated magnetic actuation device for mechanical conditioning of arrays of 3D microtissues
A microfabricated magnetic actuation device for mechanical conditioning of arrays of 3D microtissues
Fan Xu, Ruogang Zhao, Alan S. Liu, Tristin Metz, Yu Shi, Prasenjit Bose, Daniel H. Reich
Lab on a Chip  ·  01 Jan 2015  ·  doi:10.1039/c4lc01395f